NF-kB inhibitors and uses threreof

专利名称：NF-kB inhibitors and uses threreof发明人：Jetze J. Tepe申请号：US10449662申请日：20030530

公开号：US20030232998A1公开日：20031218

摘要：A new class of imidazolines as 4-position acids or esters with very potent anti-inflammatory as well as antimicrobial activity is described. The synthesis of theseimidazolines includes a multicomponent reaction applicable to a combinatorial syntheticapproach. The combination of these two key characteristics provides an effectivetherapeutic drug in the treatment of septic shock as well as many other inflammatory(arthritis and asthma) and infectious disorders. The use of this novel class of non-steroidal agents as anti-inflammatory agents (for the treatment of asthma, etc.),

antibacterial agents, and antiseptic agents is described. The compounds are also useful inthe treatment of tumors (such as cancers). The imidazolines are potent inhibitors of thetranscription factor NF-B as well as potent activity against the Gram () bacterium. Thecompositions are also useful for treating autoimmune diseases and for inhibiting rejectionof organ and tissue transplants.

申请人：BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY

更多信息请下载全文后查看