专利名称：ROTAVIRUS-LIKE PARTICLE PRODUCTION
IN PLANTS
发明人：LAVOIE, Pierre-Olivier,D'AOUST, Marc-Andre申请号：EP16739705.8申请日：20160121公开号：EP3256575A1公开日：20171220
摘要：A method of producing a rotavirus-like particle (RLP) in a plant is provided. Themethod comprises expressing within a host or host cell for example a plant, portion of aplant or plant cell one or more nucleic acid comprising one or more regulatory regionoperatively linked to a first, second and third nucleotide sequence, the regulatory regionactive in the host or host cell. The first nucleotide sequence encoding a first rotavirusprotein, the second nucleotide sequence encoding a second rotavirus protein and thethird nucleotide sequence encoding a third rotavirus protein. The first, second and thirdencode rotavirus protein NSP4 and VP2 or VP6 and VP4 or VP7. The host or host cell isincubated under conditions that permit the expression of the nucleic acids, so that NSP4and either VP2 of VP6 and VP4 or VP7 are expressed, thereby producing the RLP. Hostscomprising the RLP, compositions comprising the RLP and method for using thecomposition are also provided.
申请人：Medicago Inc.,Mitsubishi Tanabe Pharma Corporation
地址：1020 route de l'Eglise Suite 600 Québec, Québec G1V 3V9 CA,2-10, Dosho-machi3-chome Chuo-ku Osaka-shi Osaka 541-8505 JP
国籍：CA,JP
代理机构：van Kooij, Adriaan
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